Article
Role of p38 MAP kinase in endothelial cell alignment induced by fluid shear stress.
American journal of physiology. Heart and circulatory physiology - 1 Jan 2001
Azuma N, Akasaka N, Kito H, Ikeda M, Gahtan V, Sasajima T, Sumpio B E
Abstract excerpt
The p38/mitogen-activated protein (MAP) kinase-activated protein kinase 2 (MAPKAP kinase 2)/heat shock protein (HSP)25/27 pathway is thought to play a critical role in actin dynamics. In the present study, we examined whether p38 was involved in the morphological changes seen in endothelial cells (EC) exposed to shear stress. Cultured bovine aortic EC were subjected to 14 dyn/cm(2) laminar steady shear stress....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.