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Article

P2Y2 receptor modulates shear stress-induced cell alignment and actin stress fibers in human umbilical vein endothelial cells.

Cellular and molecular life sciences : CMLS - 1 Feb 2017

Sathanoori Ramasri, Bryl-Gorecka Paulina, Müller Christa E, Erb Laurie, Weisman Gary A, Olde Björn, Erlinge David

Abstract excerpt

Endothelial cells release ATP in response to fluid shear stress, which activates purinergic (P2) receptor-mediated signaling molecules including endothelial nitric oxide (eNOS), a regulator of vascular tone. While P2 receptor-mediated signaling in the vasculature is well studied, the role of P2Y2 receptors in shear stress-associated endothelial cell alignment, cytoskeletal alterations, and wound repair remains...

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Identifiers

PMID: 27652381
DOI: 10.1007/s00018-016-2365-0
PMCID: PMC5272905

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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