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Article

Osteoporosis in beta-thalassaemia major patients: analysis of the genetic background.

British journal of haematology - 1 Nov 2000

Perrotta S, Cappellini M D, Bertoldo F, Servedio V, Iolascon G, D'Agruma L, Gasparini P, Siciliani M C, Iolascon A

Abstract excerpt

Regular blood transfusions from infancy until adulthood in beta-thalassaemia major patients have substituted severe bone deformities with less marked skeletal lesions as osteoporosis. Osteoporosis is characterized by low bone mass and disruption of bone architecture, resulting in reduced bone strength and increased risk of fractures. Genetic factors have an important role in determining bone mineral density...

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Source

Identifiers

PMID: 11122085
DOI: 10.1046/j.1365-2141.2000.02382.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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