Article
Genetic and acquired predisposing factors and treatment of osteoporosis in thalassaemia major.
Journal of pediatric endocrinology & metabolism : JPEM - 1 Jan 1998
Wonke B, Jensen C, Hanslip J J, Prescott E, Lalloz M, Layton M, Erten S, Tuck S, Agnew J E, Raja K, Davies K, Hoffbrand A V
Abstract excerpt
We have previously shown a high incidence of osteopenia and osteoporosis in patients with thalassaemia major. These bone changes, were more severe in males than females, in those with diabetes mellitus and with hypogonadal-hypogonadism. Our recent studies concern the relationship of erythroid activity, assessed by serum transferrin receptors as an overall measure of anaemia, to osteoporosis. Serum transferrin...
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