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New insights into the pathophysiology and management of osteoporosis in patients with beta thalassaemia

1 Oct 2004

Abstract excerpt

Osteoporosis represents an important cause of morbidity in adult patients with thalassaemia major (TM). The pathogenesis of osteoporosis in TM is multifactorial, and includes bone marrow expansion, endocrine dysfunction and iron overload. Additional genetic factors, such as the COLIA 1 gene polymorphism, seem to play an important role in the development of low bone mass in these patients. However, the mechanisms...

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PMID: 15461618
DOI: 10.1111/j.1365-2141.2004.05143.x

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