Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of HLA-DR4 and human CD4 transgenes in mice determines the variable region beta-chain T-cell repertoire and mediates an HLA-DR-restricted immune response.

Proceedings of the National Academy of Sciences of the United States of America - 21 Jun 1994

Fugger L, Michie S A, Rulifson I, Lock C B, McDevitt G S

Abstract excerpt

Inherited susceptibility to rheumatoid arthritis is associated with genes encoding the human major histocompatibility complex class II molecule HLA-DR4. To study the immune function of HLA-DR4 and attempt to generate a murine model of rheumatoid arthritis we have produced triple transgenic mice expressing HLA-DRA*0101, -DRB1*0401, and human CD4. The expression of the HLA transgenes is driven by the promoter of...

Topics

Animals
Antibodies, Monoclonal
Antigens, CD
Arthritis, Experimental
Arthritis, Rheumatoid
CD3 Complex
CD4 Antigens
Disease Susceptibility
Female
Flow Cytometry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Genetic Variation

HLA-DQ Antigens

HLA-DR Antigens

HLA-DR4 Antigen

Humans

Mice

Mice, Inbred A

Source

Open in PubMed Open full text

Identifiers

PMID: 8016129
DOI: 10.1073/pnas.91.13.6151
PMCID: PMC44156

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8016129-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of HLA-DR4 and human CD4 transgenes in mice determines the variable region beta-chain T-cell repertoire and mediates an HLA-DR-restricted immune response.PMID 8016129Read ↗

Humanized transgenic mice expressing HLA DR4-DQ3 haplotype: reconstitution of phenotype and HLA-restricted T-cell responses.Semantic proximity Read ↗

The T cell response of HLA-DR transgenic mice to human myelin basic protein and other antigens in the presence and absence of human CD4.Semantic proximity Read ↗

A multiple transgenic mouse model with a partially humanized activation pathway for helper T cell responses.Semantic proximity Read ↗

HLA class II transgenic mice as models of human diseasesSemantic proximity Read ↗

New humanized HLA-DR4-transgenic mice that mimic the sex bias of rheumatoid arthritis.Semantic proximity Read ↗

HLA transgenic mice as humanized mouse models of disease and immunity.Semantic proximity Read ↗

Mechanism by which HLA-DR4 regulates sex-bias of arthritis in humanized mice.Semantic proximity Read ↗

Lyme disease in human DR4Dw4-transgenic mice.Semantic proximity Read ↗

Predominant selection of T cells specific for the glycosylated collagen type II epitope (263–270) in humanized transgenic mice and in rheumatoid arthritisSemantic proximity Read ↗

To B or not to B: role of B cells in pathogenesis of arthritis in HLA transgenic mice.Semantic proximity Read ↗

Human CD4-major histocompatibility complex class II (DQw6) transgenic mice in an endogenous CD4/CD8-deficient background: reconstitution of phenotype and human-restricted function.Semantic proximity Read ↗

Development of a humanized HLA-A2.1/DP4 transgenic mouse model and the use of this model to map HLA-DP4-restricted epitopes of HBV envelope protein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.