Article
Human CD4-major histocompatibility complex class II (DQw6) transgenic mice in an endogenous CD4/CD8-deficient background: reconstitution of phenotype and human-restricted function.
The Journal of experimental medicine - 1 Nov 1994
Yeung R S, Penninger J M, Kündig T M, Law Y, Yamamoto K, Kamikawaji N, Burkly L, Sasazuki T, Flavell R, Ohashi P S, Mak T W
Abstract excerpt
To reconstitute the human immune system in mice, transgenic mice expressing human CD4 and human major histocompatibility complex (MHC) class II (DQw6) molecules in an endogenous CD4- and CD8-deficient background (mCD4/8-/-), after homologous recombination, have been generated. We report that expr...
Topics
- Animals
- Antigen Presentation
- B-Lymphocytes
- CD4 Antigens
- CD8 Antigens
- HLA-DQ Antigens
- Immune Tolerance
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Transgenic
- Phenotype
- T-Lymphocytes