Article
Human CD4-major histocompatibility complex class II (DQw6) transgenic mice in an endogenous CD4/CD8-deficient background: reconstitution of phenotype and human-restricted function.
The Journal of experimental medicine - 1 Nov 1994
Yeung R S, Penninger J M, Kündig T M, Law Y, Yamamoto K, Kamikawaji N, Burkly L, Sasazuki T, Flavell R, Ohashi P S, Mak T W
Abstract excerpt
To reconstitute the human immune system in mice, transgenic mice expressing human CD4 and human major histocompatibility complex (MHC) class II (DQw6) molecules in an endogenous CD4- and CD8-deficient background (mCD4/8-/-), after homologous recombination, have been generated. We report that expression of human CD4 molecule in mCD4/8-/- mice rescues thymocyte development and completely restores the T cell...
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