Article

TP63 mediates the generation of tumour-specific chromatin loops that underlie MYC activation in radiation-induced tumorigenesis

2024-12-20

Abstract excerpt

<title>Abstract</title> <p>Alterations in 3D chromatin conformation may disrupt the interplay between promoters and distal enhancers. How gene regulatory circuits are reshaped during ionizing radiation-induced tumorigenesis remains unclear, and little is known about the mediators that drivethese processes. To decipher the chromatin alterations in radiation-induced lung cancer, we performed ATAC-seq, RNA-seq and H...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6f9e0dd1-d5d5-5fe7-98a5-d35c7d640474
DOI: 10.21203/rs.3.rs-468324/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TP63 mediates the generation of tumour-specific chromatin loops that underlie MYC activation in radiation-induced tumorigenesisDOI 10.21203/rs.3.rs-468324/v1Read

Spatial Reorganization of Chromatin Architecture Shapes the Expression Phenotype of Therapy-Induced Senescent Cells.Semantic proximity Read

Genomic retargeting of p53 and CTCF is associated with transcriptional changes during oncogenic HRas-induced transformation.Semantic proximity Read

SETDB1 fuels the lung cancer phenotype by modulating epigenome, 3D genome organization and chromatin mechanical properties.Semantic proximity Read

Radiation-induced YAP/TEAD4 binding confers non-small cell lung cancer radioresistance via promoting NRP1 transcriptionSemantic proximity Read

Genome-wide identification and analysis of A-to-I RNA editing events in the malignantly transformed cell lines from BEP2D induced by α-particles radiationSemantic proximity Read

ΔNp63 in squamous cell carcinoma: defining the oncogenic routes affecting epigenetic landscape and tumour microenvironmentSemantic proximity Read

TP63 fusions drive multicomplex enhancer rewiring, lymphomagenesis, and EZH2 dependenceSemantic proximity Read

Erlotinib induces 3D genome rearrangements in lung cancer cells activating tumor suppressor genes through FOXA2-bound EpromotersSemantic proximity Read

p63 cooperates with CTCF to modulate chromatin architecture in skin keratinocytesSemantic proximity Read

LungCancer3D: A Comprehensive Database for Integrating Lung Cancer Chromatin Architecture with Other Multi-omicsSemantic proximity Read

Radiation Resistance in KRAS-Mutated Lung Cancer Is Enabled by Stem-like Properties Mediated by an Osteopontin-EGFR Pathway.Semantic proximity Read

Galactic Cosmic Radiation Induces Persistent Epigenome Alterations Relevant to Human Lung CancerSemantic proximity Read