Article
Second stage of a genome scan of schizophrenia: study of five positive regions in an expanded sample.
American journal of medical genetics - 4 Dec 2000
Mowry B J, Ewen K R, Nancarrow D J, Lennon D P, Nertney D A, Jones H L, O'Brien M S, Thornley C E, Walters M K, Crowe R R, Silverman J M, Endicott J, Sharpe L, Hayward N K, Gladis M M, Foote S J, Levinson D F
Abstract excerpt
In a previous genome scan of 43 schizophrenia pedigrees, nonparametric linkage (NPL) scores with empirically derived pointwise P-values less than 0.01 were observed in two regions (chromosomes 2q12-13 and 10q23) and less than 0.05 in three regions (4q22-23, 9q22, and 11q21). Markers with a mean spacing of about 5 cM were typed in these regions in an expanded sample of 71 pedigrees, and NPL analyses carried out....
Topics
- Alleles
- Chromosome Mapping
- Chromosomes, Human, Pair 10
- Chromosomes, Human, Pair 11
- Chromosomes, Human, Pair 2
- Chromosomes, Human, Pair 4
- Chromosomes, Human, Pair 9
- Family Health
- Female