Article
Meta-analysis of 32 genome-wide linkage studies of schizophrenia.
Molecular psychiatry - 1 Aug 2009
Ng M Y M, Levinson D F, Faraone S V, Suarez B K, DeLisi L E, Arinami T, Riley B, Paunio T, Pulver A E, Irmansyah, Holmans P A, Escamilla M, Wildenauer D B, Williams N M, Laurent C, Mowry B J, Brzustowicz L M, Maziade M, Sklar P, Garver D L, Abecasis G R, Lerer B, Fallin M D, Gurling H M D, Gejman P V, Lindholm E, Moises H W, Byerley W, Wijsman E M, Forabosco P, Tsuang M T, Hwu H-G, Okazaki Y, Kendler K S, Wormley B, Fanous A, Walsh D, O'Neill F A, Peltonen L, Nestadt G, Lasseter V K, Liang K Y, Papadimitriou G M, Dikeos D G, Schwab S G, Owen M J, O'Donovan M C, Norton N, Hare E, Raventos H, Nicolini H, Albus M, Maier W, Nimgaonkar V L, Terenius L, Mallet J, Jay M, Godard S, Nertney D, Alexander M, Crowe R R, Silverman J M, Bassett A S, Roy M-A, Mérette C, Pato C N, Pato M T, Roos J Louw, Kohn Y, Amann-Zalcenstein D, Kalsi G, McQuillin A, Curtis D, Brynjolfson J, Sigmundsson T, Petursson H, Sanders A R, Duan J, Jazin E, Myles-Worsley M, Karayiorgou M, Lewis C M
Abstract excerpt
A genome scan meta-analysis (GSMA) was carried out on 32 independent genome-wide linkage scan analyses that included 3255 pedigrees with 7413 genotyped cases affected with schizophrenia (SCZ) or related disorders. The primary GSMA divided the autosomes into 120 bins, rank-ordered the bins within each study according to the most positive linkage result in each bin, summed these ranks (weighted for study size) for...
Topics
- Chromosomes, Human
- Female
- Genetic Linkage
- Genetic Predisposition to Disease
