Article
No association between the dopamine D3 receptor Bal I polymorphism and schizophrenia in a family-based study of a Palestinian Arab population.
American journal of medical genetics - 4 Dec 2000
Kremer I, Rietschel M, Dobrusin M, Mujaheed M, Murad I, Blanaru M, Bannoura I, Müller D J, Schulze T G, Reshef A, Gathas S, Schwab S, Wildenauer D, Bachner-Melman R, Belmaker R H, Maier W, Ebstein R P
Abstract excerpt
Several recent meta-analyses appear to show a weak but significant effect of both forms of the gly/ser DRD3 polymorphism in conferring risk for schizophrenia. Since most studies have employed the artifact-prone case-control design, we thought it worthwhile to examine the role of this polymorphism using a robust family-based strategy in an ethnic group not previously systematically studied in psychiatric genetics,...
Topics
- Alleles
- Arabs
- Cohort Studies
- Family Health
- Gene Frequency
- Genotype
- Humans
- Israel
- Polymorphism, Genetic
- Receptors, Dopamine D2