Association between schizophrenia and homozygosity at the dopamine D3 receptor gene.

doi:10.1136/jmg.29.12.858

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Article

Association between schizophrenia and homozygosity at the dopamine D3 receptor gene.

Journal of medical genetics - 1 Dec 1992

Crocq M A, Mant R, Asherson P, Williams J, Hode Y, Mayerova A, Collier D, Lannfelt L, Sokoloff P, Schwartz J C

Abstract excerpt

Disturbances in dopamine neurotransmission have been postulated to underlie schizophrenia. We report data from two independent studies of a BalI polymorphism in the dopamine D3 receptor gene in patients with schizophrenia. In both studies, more patients than controls were homozygous (p = 0.005, p...

Topics

Adult
Aged
Alleles
Base Sequence
Chi-Square Distribution
Chromosomes, Human, Pair 3
DNA
Deoxyribonucleases, Type II Site-Specific
Female
Gene Frequency
Homozygote
Humans
Male
Middle Aged
Molecular Sequence Data
Polymorphism, Restriction Fragment Length

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Identifiers

PMID: 1362221
DOI: 10.1136/jmg.29.12.858
PMCID: PMC1016201

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1362221-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Receptors, Dopamine

Receptors, Dopamine D2