A meta-analysis and transmission disequilibrium study of association between the dopamine D3 receptor gene and schizophrenia.

doi:10.1038/sj.mp.4000376

Article

A meta-analysis and transmission disequilibrium study of association between the dopamine D3 receptor gene and schizophrenia.

Molecular psychiatry - 1 Mar 1998

Williams J, Spurlock G, Holmans P, Mant R, Murphy K, Jones L, Cardno A, Asherson P, Blackwood D, Muir W, Meszaros K, Aschauer H, Mallet J, Laurent C, Pekkarinen P, Seppala J, Stefanis C N, Papadimitriou G N, Macciardi F, Verga M, Pato C, Azevedo H, Crocq M A, Gurling H, Owen M J

Abstract excerpt

We performed a meta-analysis of over 30 case-control studies of association between schizophrenia and a bi-allelic, Bali polymorphism in exon 1 of the dopamine D3 receptor gene. We observed a significant excess of both forms of homozygote in patients (P = 0.0009, odds ratio (OR) = 1.21, 95% Confi...

Topics

Alleles
Case-Control Studies
Chromosomes, Human, Pair 3
DNA
Deoxyribonucleases, Type II Site-Specific
Disease Susceptibility
Dopamine
Europe
Exons
Female

Gene Frequency

Genetic Heterogeneity

Genotype

Humans

Linkage Disequilibrium

Male

Odds Ratio

Polymerase Chain Reaction

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