Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association between homozygosity at the COMT gene locus and obsessive compulsive disorder.

American journal of medical genetics - 4 Dec 2000

Schindler K M, Richter M A, Kennedy J L, Pato M T, Pato C N

Abstract excerpt

A functional polymorphism in the coding region of the catechol O-methyltransferase (COMT) gene has been reported in previous studies to be associated with obsessive compulsive disorder (OCD), particularly in males [Karayiorgou et al., 1997, 1999]. Using a family-based population analysis, we attempted to replicate these findings in a group of 72 OCD patient/parent trios collected from Buffalo, New York, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Catechol O-Methyltransferase
Share to DNA

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to COMT gene

Share to Gene Frequency

Share to Genotype

Share to Homozygote

Share to Obsessive-Compulsive Disorder

Source

Identifiers

PMID: 11121168
DOI: 10.1002/1096-8628(20001204)96:6<721::aid-ajmg4>3.0.co;2-m

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association between homozygosity at the COMT gene locus and obsessive compulsive disorder.PMID 11121168Read ↗

Association between the COMT locus and obsessive-compulsive disorder in females but not males.Semantic proximity Read ↗

Meta-analysis of the association between the catecholamine-O-methyl-transferase gene and obsessive-compulsive disorder.Semantic proximity Read ↗

Lack of association of catechol-O-methyltransferase gene polymorphism in obsessive-compulsive disorder.Semantic proximity Read ↗

No association between anxiety disorders and catechol-O-methyltransferase polymorphism.Semantic proximity Read ↗

COMT and MAO-A polymorphisms and obsessive-compulsive disorder: a family-based association study.Semantic proximity Read ↗

Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder.Semantic proximity Read ↗

The met(158) allele of catechol-O-methyltransferase (COMT) is associated with obsessive-compulsive disorder in men: case-control study and meta-analysis.Semantic proximity Read ↗

Family-based association studies support a sexually dimorphic effect of COMT and MAOA on genetic susceptibility to obsessive-compulsive disorder.Semantic proximity Read ↗

Catechol-O-Methyltransferase Gene Polymorphisms in Specific Obsessive-Compulsive Disorder Patients' Subgroups.Semantic proximity Read ↗

Association between a catechol-o-methyltransferase polymorphism and obsessive-compulsive disorder in the Afrikaner population.Semantic proximity Read ↗

Catechol-O-methyltransferase gene Val158Met polymorphism and obsessive compulsive disorder susceptibility: a meta-analysis.Semantic proximity Read ↗

Disorder-specific genetic factors in obsessive-compulsive disorder: A comprehensive meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.