Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Catechol-O-Methyltransferase Gene Polymorphisms in Specific Obsessive-Compulsive Disorder Patients' Subgroups.

Journal of molecular neuroscience : MN - 1 Jan 2016

Melo-Felippe Fernanda Brito, de Salles Andrade Juliana Braga, Giori Isabele Gomes, Vieira-Fonseca Tamiris, Fontenelle Leonardo Franklin, Kohlrausch Fabiana Barzotti

Abstract excerpt

Pharmacological data and animal models support the hypothesis that the dopaminergic (DA) system is implicated in obsessive-compulsive disorder (OCD). Therefore, this case-control study assessed whether genetics variations in catechol-O-methyltransferase gene (COMT) could influence susceptibility to OCD and OCD features in a Brazilian sample. A sample of 199 patients with OCD and 200 healthy individuals was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to Catechol O-Methyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to COMT gene

Share to Mutation, Missense

Share to Obsessive-Compulsive Disorder

Share to Polymorphism, Single Nucleotide

Share to Sex Factors

Source

Identifiers

PMID: 26687156
DOI: 10.1007/s12031-015-0697-0

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Catechol-O-Methyltransferase Gene Polymorphisms in Specific Obsessive-Compulsive Disorder Patients' Subgroups.PMID 26687156Read ↗

Catechol-O-methyltransferase gene Val158Met polymorphism and obsessive compulsive disorder susceptibility: a meta-analysis.Semantic proximity Read ↗

The met(158) allele of catechol-O-methyltransferase (COMT) is associated with obsessive-compulsive disorder in men: case-control study and meta-analysis.Semantic proximity Read ↗

Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder.Semantic proximity Read ↗

Association of catechol-O-methyl transferase (COMT) gene -287A/G polymorphism with susceptibility to obsessive-compulsive disorder in Chinese Han population.Semantic proximity Read ↗

Reduced 3-O-methyl-dopa levels in OCD patients and their unaffected parents is associated with the low activity M158 COMT allele.Semantic proximity Read ↗

Meta-analysis of the association between the catecholamine-O-methyl-transferase gene and obsessive-compulsive disorder.Semantic proximity Read ↗

COMT Val158Met polymorphism and executive functions in obsessive-compulsive disorder.Semantic proximity Read ↗

Association between a catechol-o-methyltransferase polymorphism and obsessive-compulsive disorder in the Afrikaner population.Semantic proximity Read ↗

Catechol-O-methyltransferase (COMT): a gene contributing to sex differences in brain function, and to sexual dimorphism in the predisposition to psychiatric disorders.Semantic proximity Read ↗

Association between the COMT locus and obsessive-compulsive disorder in females but not males.Semantic proximity Read ↗

No association between anxiety disorders and catechol-O-methyltransferase polymorphism.Semantic proximity Read ↗

Disorder-specific genetic factors in obsessive-compulsive disorder: A comprehensive meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.