Article
FAP-1 association with Fas (Apo-1) inhibits Fas expression on the cell surface.
Molecular and cellular biology - 1 May 2003
Ivanov Vladimir N, Lopez Bergami Pablo, Maulit Gabriel, Sato Taka-Aki, Sassoon David, Ronai Ze'ev
Abstract excerpt
As revealed by intracellular pools of nonactive Fas (Apo-1), export of Fas to the cell surface is often impaired in human tumors, thereby inactivating Fas ligand-mediated apoptosis. Here, we demonstrate that association with Fas-associated phosphatase 1 (FAP-1) attenuates Fas export to the cell surface. Forced expression of FAP-1 reduces cell surface Fas levels and increases the intracellular pool of Fas within...
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