Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modulation of fas-mediated apoptosis in osteosarcoma cell lines.

International journal of oncology - 1 Dec 1999

Hamada T, Komiya S, Yano H, Zenmyo M, Hiraoka K, Inoue A, Morimatsu M

Abstract excerpt

Fas/APO-1 (or CD95) is a 45-kDa cell surface glycoprotein that transduces cellular death signals for apoptosis upon cross-linking with the Fas ligand, which is experimentally replaced by anti-Fas antibodies. We examined the Fas expression at the protein and mRNA levels, and susceptibility to anti-Fas-mediated apoptosis, in 14 osteosarcoma cell lines. Ten of 14 ostesarcoma cell lines constitutively expressed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Monoclonal
Share to Culture Media, Conditioned
Share to Cycloheximide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to fas Receptor

Share to Osteosarcoma

Share to Protein Isoforms

Share to Protein Synthesis Inhibitors

Share to RNA, Neoplasm

Source

Identifiers

PMID: 10568818
DOI: 10.3892/ijo.15.6.1125

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modulation of fas-mediated apoptosis in osteosarcoma cell lines.PMID 10568818Read ↗

FR901228 induces tumor regression associated with induction of Fas ligand and activation of Fas signaling in human osteosarcoma cellsSemantic proximity Read ↗

Sensitization of multidrug resistant human ostesarcoma cells to Apo2 Ligand/TRAIL-induced apoptosis by inhibition of the Akt/PKB kinaseSemantic proximity Read ↗

Bcl-xl as the most promising Bcl-2 family member in targeted treatment of chondrosarcomaSemantic proximity Read ↗

Apoptotic genes as potential markers of metastatic phenotype in human osteosarcoma cell lines.Semantic proximity Read ↗

Expression of Apo-1/Fas (CD95), Bcl-2, Bax and Bcl-x in myeloma cell lines: relationship between responsiveness to anti-Fas mab and p53 functional status.Semantic proximity Read ↗

Fas/Fas ligand regulation mediates cell death in human Ewing's sarcoma cells treated with melatoninSemantic proximity Read ↗

Fas receptor-mediated apoptosis: a clinical application?Semantic proximity Read ↗

Differential involvement of the CD95 (Fas/APO-1) receptor/ligand system on apoptosis induced by the wild-type p53 gene transfer in human cancer cellsSemantic proximity Read ↗

Selective targeting of death receptor 5 circumvents resistance of MG-63 osteosarcoma cells to TRAIL-induced apoptosis.Semantic proximity Read ↗

Deficient activation of CD95 (APO-1/Fas)-mediated apoptosis: a potential factor of multidrug resistance in human renal cell carcinoma.Semantic proximity Read ↗

Syndecan-2 overexpression induces osteosarcoma cell apoptosis: Implication of syndecan-2 cytoplasmic domain and JNK signaling.Semantic proximity Read ↗

Epidermal growth factor receptor targeting enhances adenoviral vector based suicide gene therapy of osteosarcomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.