Article
The genetics and molecular pathology of Alzheimer's disease: roles of amyloid and the presenilins.
Neurologic clinics - 1 Nov 2000
Selkoe D J
Abstract excerpt
The study of Alzheimer's disease (AD) has had more than its share of controversy. In the last few years, however, considerable consensus has been developed that certain molecular events in the brain occur many years or decades before clinical symptoms, and a rough outline of the pathogenic cascade has emerged from the studies of many investigators. Progress in two broad areas has led to this consensus: molecular...
Topics
- Aged
- Alzheimer Disease
- Amyloid
- Brain
- Gene Expression
- Genetic Markers
- Genetic Predisposition to Disease
- Humans
- Membrane Proteins
- Presenilin-1
- Presenilin-2