Article
Tumor metastasis and the reciprocal regulation of prometastatic and antimetastatic factors by nuclear factor kappaB.
Cancer research - 1 Dec 2000
Andela V B, Schwarz E M, Puzas J E, O'Keefe R J, Rosier R N
Abstract excerpt
To investigate the role of the transcription factor nuclear factor kappaB (NFkappaB) in tumor metastasis, we generated a murine lung alveolar carcinoma cell line (Line 1) defective in NFkappaB-signaling by retroviral delivery of a dominant negative inhibitor of NFkappaB. The NFkappaB signal block...
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