Article
The role of NF-kappaB/IkappaB proteins in cancer: implications for novel treatment strategies.
Surgical oncology - 1 Nov 1999
Schwartz S A, Hernandez A, Mark Evers B
Abstract excerpt
The nuclear factor-kappaB (NF-kappaB) family of transcription factors are involved in multiple cellular processes, including cytokine gene expression, cellular adhesion, cell cycle activation, apoptosis and oncogenesis. Constitutive activation of NF-kappaB has been described in a number of solid tumors and this activation appears to affect cancer cell survival. Inhibition of NF-kappaB has been shown to enhance...
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