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Article

NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression

16 Aug 2004

Abstract excerpt

The transcription factor NF-kappaB is activated in a range of human cancers and is thought to promote tumorigenesis, mainly due to its ability to protect transformed cells from apoptosis. To investigate the role of NF-kappaB in epithelial plasticity and metastasis, we utilized a well-characterized in vitro/in vivo model of mammary carcinogenesis that depends on the collaboration of the Ha-Ras oncoprotein and...

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PMID: 15314694
DOI: 10.1172/jci21358

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