Article

NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression

2004-08-16

Abstract excerpt

The transcription factor NF-B is activated in a range of human cancers and is thought to promote tumorigenesis, mainly due to its ability to protect transformed cells from apoptosis. To investigate the role of NF-B in epithelial plasticity and metastasis, we utilized a well-characterized in vitro/in vivo model of mammary carcinogenesis that depends on the collaboration of the Ha-Ras oncoprotein and TGF-. We show h...

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Literature Corpus work: 3881d70f-a79b-51f9-bf99-a58e353676db
DOI: 10.1172/jci200421358

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