Article
Molecular determinants of metastatic transformation.
Environmental health perspectives - 1 Jun 1991
Egan S E, Wright J A, Greenberg A H
Abstract excerpt
In recent years, experimental systems have developed to analyze genetic and epigenetic regulation of the metastatic phenotype. Numerous studies have uncovered a potent role for transforming oncogenes in metastatic conversion. In addition, it has been shown that oncoprotein products operate in a dose-dependent fashion. The continued expression of oncoproteins is required to induce and regulate metastatic...
Topics
- 3T3 Cells
- Animals
- Cell Transformation, Neoplastic
- Epistasis, Genetic
- Gene Amplification
- Gene Expression Regulation, Neoplastic
- Genes, Dominant
- Genes, Recessive
- Genes, Tumor Suppressor
- Genes, ras
- Growth Substances