Article
Molecular determinants of metastatic transformation.
Environmental health perspectives - 1 Jun 1991
Egan S E, Wright J A, Greenberg A H
Abstract excerpt
In recent years, experimental systems have developed to analyze genetic and epigenetic regulation of the metastatic phenotype. Numerous studies have uncovered a potent role for transforming oncogenes in metastatic conversion. In addition, it has been shown that oncoprotein products operate in a dose-dependent fashion. The continued expression of oncoproteins is required to induce and regulate metastatic...
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