Article
Differential chromatin packaging of genomic imprinted regions between expressed and non-expressed alleles.
Human molecular genetics - 12 Dec 2000
Watanabe T, Yoshimura A, Mishima Y, Endo Y, Shiroishi T, Koide T, Sasaki H, Asakura H, Kominami R
Abstract excerpt
Chromosomal regions subject to genomic imprinting comprise a functional domain exhibiting parental-specific expression of genes and hence may take a unique chromatin structure. Here we have examined the chromatin packaging state of allelic sites in the Zfp127/Snrpn locus on mouse chromosome 7 and in the Igf2r locus on mouse chromosome 17 with an assay consisting of chromatin fractionation and allele-specific...
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