Article
Cross-regulation of competence pheromone production and export in the early control of transformation in Streptococcus pneumoniae.
Molecular microbiology - 1 Nov 2000
Martin B, Prudhomme M, Alloing G, Granadel C, Claverys J P
Abstract excerpt
Two operons, comAB and comCDE, play a key role in the co-ordination of spontaneous competence development in cultures of Streptococcus pneumoniae. ComAB is required for export of the comC-encoded competence-stimulating peptide (CSP). Upon CSP binding, the histidine kinase ComD activates ComE, its cognate response regulator, required for autoinduction of comCDE and for induction of the late competence genes. To...
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