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Article

The com locus controls genetic transformation in Streptococcus pneumoniae.

Molecular microbiology - 1 Feb 1997

Cheng Q, Campbell E A, Naughton A M, Johnson S, Masure H R

Abstract excerpt

Genetic exchange by natural transformation in Streptococcus pneumoniae occurs in a cell-density dependent process and is initiated by a small extracellular signalling molecule, the competence-stimulating peptide (CSP). comC, the gene for this peptide, has previously been identified and encodes a 44 amino acid pre-peptide that is apparently processed to an active molecule that consists of the C-terminal 17 amino...

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Identifiers

PMID: 9157240
DOI: 10.1046/j.1365-2958.1997.2481617.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The com locus controls genetic transformation in Streptococcus pneumoniae.PMID 9157240Read ↗

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Expression and maintenance of ComD–ComE, the two‐component signal‐transduction system that controls competence of <i>Streptococcus pneumoniae</i>Semantic proximity Read ↗

Direct involvement of DprA, the transformation-dedicated RecA loader, in the shut-off of pneumococcal competence.Semantic proximity Read ↗

Inhibition of competence development in Streptococcus pneumoniae by increased basal-level expression of the ComDE two-component regulatory system.Semantic proximity Read ↗

Sensor domain of histidine kinase ComD confers competence pherotype specificity in Streptoccoccus pneumoniae.Semantic proximity Read ↗

Genetic diversity of the streptococcal competence (com) gene locus.Semantic proximity Read ↗

Transformation in Streptococcus pneumoniae: mosaic genes and the regulation of competence.Semantic proximity Read ↗

Temporal Regulation of the Transformasome and Competence Development in Streptococcus suisSemantic proximity Read ↗

ComX is a unique link between multiple quorum sensing outputs and competence in <i>Streptococcus pneumoniae</i>Semantic proximity Read ↗

Fine‐tuning cellular levels of DprA ensures transformant fitness in the human pathogen Streptococcus pneumoniaeSemantic proximity Read ↗

Exit from competence for genetic transformation in Streptococcus pneumoniae is regulated at multiple levels.Semantic proximity Read ↗

Identification of a new regulator in Streptococcus pneumoniae linking quorum sensing to competence for genetic transformation.Semantic proximity Read ↗

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