Article
Exit from competence for genetic transformation in Streptococcus pneumoniae is regulated at multiple levels.
PloS one - 1 Jan 2013
Weng Liming, Piotrowski Andrew, Morrison Donald A
Abstract excerpt
Development of natural competence in S. pneumoniae entails coordinated expression of two sets of genes. Early gene expression depends on ComE, a response regulator activated by the pheromone CSP (Competence-Stimulating-Peptide). Subsequently, an early gene product (the alternative sigma factor ComX) activates expression of late genes, establishing the competent state. Expression of both sets of genes is...
Topics
- Base Sequence
- Blotting, Western
- DNA Primers
- Electrophoresis, Polyacrylamide Gel
- Genes, Bacterial
- Kinetics
- Mutation
- Streptococcus pneumoniae
- Transformation, Genetic
- Two-Hybrid System Techniques