Expression and maintenance of ComD–ComE, the two‐component signal‐transduction system that controls competence of <i>Streptococcus pneumoniae</i>

Abstract excerpt

A secreted competence-stimulating peptide (CSP), encoded by comC, constitutes, together with the two-component system ComD-ComE, the master switch for competence induction in Streptococcus pneumoniae. Interaction between CSP and its membrane-bound histidine-kinase receptor, ComD, is believed to lead to autophosphorylation of ComD, which then transphosphorylates the ComE response regulator to activate...

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