Article
A secondary drug resistance mutation of TEM-1 beta-lactamase that suppresses misfolding and aggregation.
Proceedings of the National Academy of Sciences of the United States of America - 2 Jan 2001
Sideraki V, Huang W, Palzkill T, Gilbert H F
Abstract excerpt
In Gram-negative bacteria, TEM-1 beta-lactamase provides the major mechanism of plasmid-mediated beta-lactam resistance. Natural variants of TEM-1 with increased antibiotic resistance have appeared in response to the use of extended-spectrum beta-lactam antibiotics (e.g., ceftazidime) and beta-lactamase inhibitors (e.g., clavulanic acid). Some of the variant enzymes are more efficient at catalyzing beta-lactam...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.