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Article

In vivo impact of Met221 substitution in GOB metallo-β-lactamase.

Antimicrobial agents and chemotherapy - 1 Apr 2012

Morán-Barrio Jorgelina, Lisa María-Natalia, Vila Alejandro J

Abstract excerpt

Metallo-β-lactamases (MβLs) represent one of the main mechanisms of bacterial resistance against β-lactam antibiotics. The elucidation of their mechanism has been limited mostly by the structural diversity among their active sites. All MβLs structurally characterized so far present a Cys or a Ser residue at position 221, which is critical for catalysis. GOB lactamases stand as an exception within this picture,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22252824
DOI: 10.1128/AAC.05418-11
PMCID: PMC3318309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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