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Article

Role of rhodopsin and arrestin phosphorylation in retinal degeneration of Drosophila.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Aug 2012

Kristaponyte Inga, Hong Yuan, Lu Haiqin, Shieh Bih-Hwa

Abstract excerpt

Arrestins belong to a family of multifunctional adaptor proteins that regulate internalization of diverse receptors including G-protein-coupled receptors (GPCRs). Defects associated with endocytosis of GPCRs have been linked to human diseases. We used enhanced green fluorescent protein-tagged arrestin 2 (Arr2) to monitor the turnover of the major rhodopsin (Rh1) in live Drosophila. We demonstrate that during...

Topics

Animals
Animals, Genetically Modified
Arrestins
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Disease Models, Animal
Drosophila
Drosophila Proteins
Enzyme Inhibitors
Gene Expression Regulation
Green Fluorescent Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Mutation

Phospholipase C beta

Phosphorylation

Photoreceptor Cells, Vertebrate

Protein Binding

Retinal Degeneration

Rhodopsin

Source

Open in PubMed Open full text

Identifiers

PMID: 22855823
DOI: 10.1523/JNEUROSCI.0565-12.2012
PMCID: PMC3430379

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Role of rhodopsin and arrestin phosphorylation in retinal degeneration of Drosophila.PMID 22855823Read ↗

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