Article
The role of histone acetylation in the allelic expression of the imprinted human insulin-like growth factor II gene.
Biochemical and biophysical research communications - 20 Oct 1998
Hu J F, Oruganti H, Vu T H, Hoffman A R
Abstract excerpt
Reversible histone acetylation plays a central role in X chromosome inactivation. Histones are hypoacetylated on the heavily methylated inactive X chromosome and are hyperacetylated in the unmethylated "CpG islands" in animal genomes. We have investigated whether histone acetylation is involved i...
Topics
- Acetylation
- Alleles
- Animals
- Butyrates
- Cells, Cultured
- DNA Primers
- Enzyme Inhibitors
- Female
- Fibroblasts
- Gene Expression Regulation
- Genomic Imprinting
- Histone Deacetylase Inhibitors
- Histones
- Humans
- Hydroxamic Acids
- Insulin-Like Growth Factor II
- Polymerase Chain Reaction
- Skin