Article
The role of histone acetylation in the allelic expression of the imprinted human insulin-like growth factor II gene.
Biochemical and biophysical research communications - 20 Oct 1998
Hu J F, Oruganti H, Vu T H, Hoffman A R
Abstract excerpt
Reversible histone acetylation plays a central role in X chromosome inactivation. Histones are hypoacetylated on the heavily methylated inactive X chromosome and are hyperacetylated in the unmethylated "CpG islands" in animal genomes. We have investigated whether histone acetylation is involved in the regulation of the allelic expression of insulin-like growth factor II (IGF2), a maternally imprinted gene. HSK09,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
