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Article

c-IAP1 Is Cleaved by Caspases to Produce a Proapoptotic C-terminal Fragment

1 Mar 2001

Abstract excerpt

Although human c-IAP1 and c-IAP2 have been reported to possess antiapoptotic activity against a variety of stimuli in several mammalian cell types, we observed that full-length c-IAP1 and c-IAP2 failed to protect cells from apoptosis induced by Bax overexpression, tumor necrosis factor alpha treatment or Sindbis virus infection. However, deletion of the C-terminal RING domains of c-IAP1 and c-IAP2 restored...

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PMID: 11106668
DOI: 10.1074/jbc.m010259200

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