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Article

Characterization of XIAP-Deficient Mice

1 May 2001

Abstract excerpt

The inhibitor of apoptosis protein (IAP) family consists of a number of evolutionarily conserved proteins that function to inhibit programmed cell death. X-linked IAP (XIAP) was cloned due to its sequence homology with other family members and has previously been shown to prevent apoptosis by binding to active caspases 3, 7, and 9 in vitro. XIAP transcripts can be found in a variety of tissues, and the protein...

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Identifiers

PMID: 11313486
DOI: 10.1128/mcb.21.10.3604-3608.2001

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