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Article

Sequence variation at two eosinophil-associated ribonuclease loci in humans.

Genetics - 1 Dec 2000

Zhang J, Rosenberg H F

Abstract excerpt

Host defense against invading pathogens is of great importance to the survival of higher organisms. We have been studying the evolution of mammalian eosinophil-associated ribonucleases (EARs), which are members of the ribonuclease A superfamily with known antipathogen activities. Earlier studies showed that positive selection promoted rapid diversification of paralogous EAR genes in both primates and rodents....

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Identifiers

PMID: 11102386
DOI: 10.1093/genetics/156.4.1949
PMCID: PMC1461363

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