Sequence variation at two eosinophil-associated ribonuclease loci in humans.

doi:10.1093/genetics/156.4.1949

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Article

Sequence variation at two eosinophil-associated ribonuclease loci in humans.

Genetics - 1 Dec 2000

Zhang J, Rosenberg H F

Abstract excerpt

Host defense against invading pathogens is of great importance to the survival of higher organisms. We have been studying the evolution of mammalian eosinophil-associated ribonucleases (EARs), which are members of the ribonuclease A superfamily with known antipathogen activities. Earlier studies showed that positive selection promoted rapid diversification of paralogous EAR genes in both primates and rodents....

Topics

Alleles
Amino Acid Sequence
Animals
Base Sequence
Blood Proteins
Eosinophil Cationic Protein
Eosinophil Granule Proteins
Eosinophil-Derived Neurotoxin
Evolution, Molecular
Genes
Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Haplotypes

Humans

Infections

Linkage Disequilibrium

Models, Genetic

Molecular Sequence Data

Multigene Family

Source

Open in PubMed Open full text

Identifiers

PMID: 11102386
DOI: 10.1093/genetics/156.4.1949
PMCID: PMC1461363

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