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Article

Genetic diversity of human RNase 8.

BMC genomics - 24 Jan 2012

Chan Calvin C, Moser Jennifer M, Dyer Kimberly D, Percopo Caroline M, Rosenberg Helene F

Abstract excerpt

BACKGROUND: Ribonuclease 8 is a member of the RNase A family of secretory ribonucleases; orthologs of this gene have been found only in primate genomes. RNase 8 is a divergent paralog of RNase 7, which is lysine-enriched, highly conserved, has prominent antimicrobial activity, and is expressed in both normal and diseased skin; in contrast, the physiologic function of RNase 8 remains uncertain. Here, we examine...

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Identifiers

PMID: 22272736
DOI: 10.1186/1471-2164-13-40
PMCID: PMC3295680

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