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Article

Complementary advantageous substitutions in the evolution of an antiviral RNase of higher primates.

Proceedings of the National Academy of Sciences of the United States of America - 16 Apr 2002

Zhang Jianzhi, Rosenberg Helene F

Abstract excerpt

An improved understanding of the evolution of gene function at the molecular level may provide significant insights into the origin of biological novelty and adaptation. With the approach of ancestral protein reconstruction, we here address the question of how a dramatically enhanced ribonucleolytic activity and the related antiviral activity evolved in a recently duplicated ribonuclease (eosinophil-derived...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11917138
DOI: 10.1073/pnas.072626199
PMCID: PMC122796

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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