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Article

Positive selection on the gene RNASEL: correlation between patterns of evolution and function.

Molecular biology and evolution - 1 Oct 2012

Jin Wei, Wu Dong-Dong, Zhang Xin, Irwin David M, Zhang Ya-Ping

Abstract excerpt

RNASEL is a 2-5A-dependent endoribonuclease that is a component of the interferon-induced 2-5A system, which plays a crucial role in the antiviral and apoptotic activities of interferons. In humans, many polymorphic sites within the RNASEL gene have been associated with an increased risk of developing prostate cancer. Here, we obtained coding sequences for the RNASEL gene from 11 primates and found evidence that...

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Identifiers

PMID: 22513284
DOI: 10.1093/molbev/mss123

Genes

RNASEL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Positive selection on the gene RNASEL: correlation between patterns of evolution and function.PMID 22513284Read ↗

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Genetic variation in RNASEL and risk for prostate cancer in a population-based case-control study.Semantic proximity Read ↗

Mapping of the Human <i>RNASEL</i> Promoter and Expression in Cancer and Normal CellsSemantic proximity Read ↗

Putting pleiotropy and selection into context defines a new paradigm for interpreting genetic data.Semantic proximity Read ↗

Functional and Structural Consequences of Damaging Single Nucleotide Polymorphisms in Human Prostate Cancer Predisposition Gene RNASEL.Semantic proximity Read ↗

Germline mutation in RNASEL predicts increased risk of head and neck, uterine cervix and breast cancer.Semantic proximity Read ↗

RNase L Suppresses Androgen Receptor Signaling, Cell Migration and Matrix Metalloproteinase Activity in Prostate Cancer Cells.Semantic proximity Read ↗

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