Positive selection on the gene RNASEL: correlation between patterns of evolution and function.

doi:10.1093/molbev/mss123

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Article

Positive selection on the gene RNASEL: correlation between patterns of evolution and function.

Molecular biology and evolution - 1 Oct 2012

Jin Wei, Wu Dong-Dong, Zhang Xin, Irwin David M, Zhang Ya-Ping

Abstract excerpt

RNASEL is a 2-5A-dependent endoribonuclease that is a component of the interferon-induced 2-5A system, which plays a crucial role in the antiviral and apoptotic activities of interferons. In humans, many polymorphic sites within the RNASEL gene have been associated with an increased risk of developing prostate cancer. Here, we obtained coding sequences for the RNASEL gene from 11 primates and found evidence that...

Topics

Amino Acid Substitution
Animals
Base Sequence
Endoribonucleases
Evolution, Molecular
Gene Frequency
Genetics, Population
Geography
Haplotypes
Humans
Incidence
Likelihood Functions
Male
Mammals
Phylogeny
Polymorphism, Single Nucleotide
Prostatic Neoplasms
Selection, Genetic

Source

Open in PubMed

Identifiers

PMID: 22513284
DOI: 10.1093/molbev/mss123

Genes

RNASEL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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