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Article

Compensatory Evolution in Rifampin-Resistant <i>Escherichia coli</i>

1 Dec 2000

Abstract excerpt

This study examines the intrinsic fitness burden associated with RNA polymerase (rpoB) mutations conferring rifampin resistance in Escherichia coli K12 (MG1655) and explores the nature of adaptation to the costs of resistance. Among 28 independent Rif(r) mutants, the per-generation fitness burden (in the absence of rifampin) ranged from 0 to 28%, with a median of 6.4%. We detected no relationship between the...

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PMID: 11102350
DOI: 10.1093/genetics/156.4.1471

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