Article
Rad26, the transcription-coupled repair factor in yeast, is required for removal of stalled RNA polymerase-II following UV irradiation.
PloS one - 1 Jan 2013
Ghosh-Roy Sounak, Das Dhiman, Chowdhury Debarati, Smerdon Michael J, J Smerdon Michael, Chaudhuri Ronita Nag
Abstract excerpt
Transcription coupled nucleotide excision repair (TCR) is a major pathway responsible for removal of helix distorting DNA lesions from transcriptionally active regions of the genome. Rad26, a key factor of the TCR pathway, is known to play a role during early steps of TCR. Here, we show that Rad26-mediated TCR is not absolutely dependent on active transcription elongation in budding yeast. As per our results,...
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