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Article

Coevolution of transcriptional and allosteric regulation at the chorismate metabolic branch point of Saccharomyces cerevisiae.

Proceedings of the National Academy of Sciences of the United States of America - 5 Dec 2000

Krappmann S, Lipscomb W N, Braus G H

Abstract excerpt

Control of transcription and enzyme activities are two interwoven regulatory systems essential for the function of a metabolic node. Saccharomyces cerevisiae strains differing in enzyme activities at the chorismate branch point of aromatic amino acid biosynthesis were constructed by recombinant DNA technology. Expression of an allosterically unregulated, constitutively activated chorismate mutase encoded by the...

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Identifiers

PMID: 11095720
DOI: 10.1073/pnas.240469697
PMCID: PMC17619

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