Separation of inhibition and activation of the allosteric yeast chorismate mutase.

doi:10.1073/pnas.95.6.2868

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Article

Separation of inhibition and activation of the allosteric yeast chorismate mutase.

Proceedings of the National Academy of Sciences of the United States of America - 17 Mar 1998

Schnappauf G, Lipscomb W N, Braus G H

Abstract excerpt

Yeast chorismate mutase (EC 5.4.99.5) shows homotropic activation by the substrate, allosteric activation by tryptophan, and allosteric inhibition by tyrosine. In this study mutants of chorismate mutase have been found that remain sensitive to one allosteric effector (tryptophan) but insensitive...

Topics

Allosteric Regulation
Allosteric Site
Chorismate Mutase
Enzyme Activation
Models, Biological
Models, Molecular
Mutation
Protein Structure, Secondary
Saccharomyces cerevisiae
Tryptophan
Tyrosine

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