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Article

Evolution of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase-encoding genes in the yeast Saccharomyces cerevisiae.

Proceedings of the National Academy of Sciences of the United States of America - 12 Jul 2005

Helmstaedt Kerstin, Strittmatter Axel, Lipscomb William N, Braus Gerhard H

Abstract excerpt

The shikimate pathway resulting in three aromatic amino acids is initiated in different organisms by two and three 3-deoxy-d-arabino-heptulosonate-7-phosphate synthases, respectively. Aro3p and Aro4p are the yeast enzymes feedback-inhibited by phenylalanine and tyrosine, respectively. A yeast strain deficient in the general control transcriptional regulatory system of amino acid biosynthesis is unable to live in...

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Identifiers

PMID: 15987779
DOI: 10.1073/pnas.0504238102
PMCID: PMC1175010

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