Mutations in the regulatory subunit of yeast acetohydroxyacid synthase affect its activation by MgATP.

doi:10.1042/BJ20051793

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Article

Mutations in the regulatory subunit of yeast acetohydroxyacid synthase affect its activation by MgATP.

The Biochemical journal - 15 Apr 2006

Lee Yu-Ting, Duggleby Ronald G

Abstract excerpt

Isoleucine, leucine and valine are synthesized via a common pathway in which the first reaction is catalysed by AHAS (acetohydroxyacid synthase; EC 2.2.1.6). This heterotetrameric enzyme is composed of a larger subunit that contains the catalytic machinery and a smaller subunit that plays a regul...

Topics

Acetolactate Synthase
Adenosine Triphosphate
Amino Acid Sequence
Amino Acids, Branched-Chain
Catalytic Domain
Enzyme Activation
Models, Biological
Molecular Sequence Data
Mutagenesis, Site-Directed
Mutation
Protein Subunits
Yeasts

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