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Article

Mechanisms of catalysis and allosteric regulation of yeast chorismate mutase from crystal structures.

Structure (London, England : 1993) - 15 Nov 1997

Sträter N, Schnappauf G, Braus G, Lipscomb W N

Abstract excerpt

BACKGROUND: Chorismate mutase (CM) catalyzes the Claisen rearrangement of chorismate to prephenate, notably the only known enzymatically catalyzed pericyclic reaction in primary metabolism. Structures of the enzyme in complex with an endo-oxabicyclic transition state analogue inhibitor, previously determined for Bacillus subtilis and Escherichia coli CM, provide structural insight into the enzyme mechanism. In...

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PMID: 9384560
DOI: 10.1016/s0969-2126(97)00294-3

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