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Article

A glutamate-gated chloride channel as the mite-specific target-site of dicofol and other diphenylcarbinol acaricides.

Communications biology - 13 Nov 2023

Vandenhole Marilou, Mermans Catherine, De Beer Berdien, Xue Wenxin, Zhao Yilan, Ozoe Yoshihisa, Liu Genyan, Dermauw Wannes, Van Leeuwen Thomas

Abstract excerpt

Dicofol has been widely used to control phytophagous mites. Although dicofol is chemically related to DDT, its mode of action has remained elusive. Here, we mapped dicofol resistance in the spider mite Tetranychus urticae to two genomic regions. Each region harbored a glutamate-gated chloride channel (GluCl) gene that contained a mutation-G314D or G326E-known to confer resistance against the unrelated acaricide...

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Identifiers

PMID: 37957415
DOI: 10.1038/s42003-023-05488-5
PMCID: PMC10643420

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