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Article

Coupled release of eukaryotic translation initiation factors 5B and 1A from 80S ribosomes following subunit joining.

Molecular and cellular biology - 1 Mar 2007

Fringer Jeanne M, Acker Michael G, Fekete Christie A, Lorsch Jon R, Dever Thomas E

Abstract excerpt

The translation initiation GTPase eukaryotic translation initiation factor 5B (eIF5B) binds to the factor eIF1A and catalyzes ribosomal subunit joining in vitro. We show that rapid depletion of eIF5B in Saccharomyces cerevisiae results in the accumulation of eIF1A and mRNA on 40S subunits in vivo, consistent with a defect in subunit joining. Substituting Ala for the last five residues in eIF1A (eIF1A-5A) impairs...

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Identifiers

PMID: 17242201
DOI: 10.1128/MCB.02254-06
PMCID: PMC1820483

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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