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Article

A protease-resistant immunotoxin against CD22 with greatly increased activity against CLL and diminished animal toxicity.

Blood - 16 Apr 2009

Weldon John E, Xiang Laiman, Chertov Oleg, Margulies Inger, Kreitman Robert J, FitzGerald David J, Pastan Ira

Abstract excerpt

Immunotoxins based on Pseudomonas exotoxin A (PE) are promising anticancer agents that combine a variable fragment (Fv) from an antibody to a tumor-associated antigen with a 38-kDa fragment of PE (PE38). The intoxication pathway of PE immunotoxins involves receptor-mediated internalization and tr...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18988862
DOI: 10.1182/blood-2008-08-173195
PMCID: PMC2670794

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18988862-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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