Article
Phenotypic evidence of faulty neuronal norepinephrine reuptake in essential hypertension.
Hypertension (Dallas, Tex. : 1979) - 1 Nov 2000
Rumantir M S, Kaye D M, Jennings G L, Vaz M, Hastings J A, Esler M D
Abstract excerpt
Previous reports suggest that neuronal norepinephrine (NE) reuptake may be impaired in essential hypertension, perhaps because of dysfunction of the NE transporter, although the evidence is inconclusive. To further test this proposition, we applied phenotypically relevant radiotracer methodology, infusion of tritiated NE and quantification of NE metabolites, to 34 healthy lean subjects (body mass index <27.0...
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