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Article

Sympathetic Overactivation in the Resistant Hypertensive Phenotype: A Meta-Analysis of Published Studies.

Hypertension (Dallas, Tex. : 1979) - 1 Aug 2025

Grassi Guido, Quarti-Trevano Fosca, Cuspidi Cesare, Sanidas Elias, Mancia Giuseppe, Thomopoulos Costas

Abstract excerpt

BACKGROUND: Indirect and direct approaches to assess sympathetic cardiovascular drive have shown that patients with essential hypertension responsive to the blood pressure-lowering effects of antihypertensive drugs are characterized by a pronounced adrenergic overactivity. Whether an emerging clinical hypertensive phenotype such as drug-resistant hypertension (RHT) is also characterized by sympathetic activation...

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Identifiers

PMID: 40528744
DOI: 10.1161/HYPERTENSIONAHA.125.24749
PMCID: PMC12258805

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